Claudia Jessen-Trefzer Lab - old bugs novel drugs

Two-component systems from mycobacteria

Besides membrane transporters, other potentially interesting drug targets exist within the mycobacterial membrane; as for example proteins that belong to the class of two-component systems (TCS). Two component systems are known to play pivotal roles in signaling mechanisms and are major regulatory systems for bacterial adaptation to environmental changes with important roles in pathogenesis and virulence.

The two-component system MSMEG_0244/0246

In our laboratory, we investigate a particular two-component system from Mycobacterium smegmatis, MSMEG_0244/0246. Recently, we have shown that this TCS is involved in biofilm formation and cell wall lipid synthesis. Our main focus is to validate the hypothesis that this system has more interaction partners and is a functional three component system.

For more information, please see The Two-Component Locus MSMEG_0244/0246 Together With MSMEG_0243 Affects Biofilm Assembly in M. smegmatis Correlating With Changes in Phosphatidylinositol Mannosides Acylation

Test tubes
Test tubes