Mycobacterial Nanocompartments - Encapsulins
Exploring mycobacterial encapsulins for their potential application in synthetic biology, biotechnology and in the area of biomaterials is the main aim of this sub-project. Towards this goal we synthesize chemical catalysts and screen them for their ability to i) enter the encapsulin and ii) perform catalysis in buffers and live cells. We also plan to engineer photo-active capsules and to control pore dynamics. For more information please see: Inside a shell - organometallic catalysis inside encapsulin nanoreactors and A dual-metal-catalyzed sequential cascade reaction in an engineered protein cage.
