Publications

From benzothiazinones to four phosphates at one blow - see the complete list of publications below.

Journal Articles

RSC Chemical Biology

A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor

Our study demonstrates that encapsulating tandem nitroreductase NfsB within encapsulins, along with pore mutations, enhances enzyme activity, with cryo-EM revealing its structural architecture and multiple pore states.

Contributors: Mariia Zmyslia, Michael J. Capper, Michael Grimmeisen, Kerstin Sartory, Benedikt Deuringer, Mohamed Abdelsalam, Kaiwei Shen, Manfred Jung, Wolfgang Sippl, Hans-Georg Koch, Laurine Kaul, Regine Süss, Jesko Köhnke, Claudia Jessen-Trefzer
Publication Date: 2025

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Archiv der Pharmazie

Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells

Contributors: Mohamed Abdelsalam, Mariia Zmyslia, Karin Schmidtkunz, Anita Vecchio, Sebastian Hilscher, Hany S. Ibrahim, Mike Schutkowski, Manfred Jung, Claudia Jessen‐Trefzer, Wolfgang Sippl
Publication Date: 2024-2

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Proteomes

Deep Proteomic Investigation of Metabolic Adaptation in Mycobacteria under Different Growth Conditions

Contributors: Mariia Zmyslia, Klemens Fröhlich, Trinh Dao, Alexander Schmidt, Claudia Jessen-Trefzer
Publication Date: 2023-12-7

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ChemBioChem

Increasing the Selectivity of Light‐Active Antimicrobial Agents – Or How To Get a Photosensitizer to the Desired Target

Contributors: Michael Grimmeisen, Claudia Jessen‐Trefzer
Publication Date: 2023-9-15

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Angewandte Chemie International Edition

A Dual‐Metal‐Catalyzed Sequential Cascade Reaction in an Engineered Protein Cage**

Contributors: Paul Ebensperger, Mariia Zmyslia, Philipp Lohner, Judith Braunreuther, Benedikt Deuringer, Anita Becherer, Regine Süss, Anna Fischer, Claudia Jessen‐Trefzer
Publication Date: 2023-4-11

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Biological Chemistry

Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis

Contributors: Paul Ebensperger, Claudia Jessen-Trefzer
Publication Date: 2022-3-28

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Biological Chemistry

Chemical biology in drug discovery

Contributors: Stephan M. Hacker, Claudia Jessen-Trefzer
Publication Date: 2022-3-28

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Angewandte Chemie International Edition

Inside a Shell – Organometallic Catalysis Inside Encapsulin Nanoreactors

Contributors: Philipp Lohner, Mariia Zmyslia, Johann Thurn, Jasmin K. Pape, Ruta Gerasimaite, Jan Keller-Findeisen, Saskia Groeer, Benedikt Deuringer, Regine Süss, Andreas Walther, Stefan W. Hell, Grazvydas Lukinavicius, Thorsten Hugel, Claudia Jessen-Trefzer
Publication Date: 2021-8

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ACS Infectious Diseases

Pyridinium Modified Anthracenes and Their Endoperoxides Provide a Tunable Scaffold with Activity against Gram-Positive and Gram-Negative Bacteria

Contributors: Xuan Wang, Tamara Bittner, Martin Milanov, Laurine Kaul, Stephan Mundinger, Hans-Georg Koch, Claudia Jessen-Trefzer, Henning J. Jessen
Publication Date: 2021-8-13

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RSC Medicinal Chemistry

Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors

Contributors: Andrea Unzue, Claudia Jessen-Trefzer, Dimitrios Spiliotopoulos, Eugenio Gaudio, Chiara Tarantelli, Jing Dong, Hongtao Zhao, Johanna Pachmayr, Stefan Zahler, Elena Bernasconi, Giulio Sartori, Luciano Cascione, Francesco Bertoni, Paweł Śledź, Amedeo Caflisch, Cristina Nevado
Publication Date: 2020

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Frontiers in Microbiology

The Two-Component Locus MSMEG_0244/0246 Together With MSMEG_0243 Affects Biofilm Assembly in M. smegmatis Correlating With Changes in Phosphatidylinositol Mannosides Acylation

Contributors: Miaomaio Li, Henrich Gašparovič, Xing Weng, Si Chen, Jana Korduláková, Claudia Jessen-Trefzer
Publication Date: 2020-9-11

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The Journal of Organic Chemistry

Four Phosphates at One Blow: Access to Pentaphosphorylated Magic Spot Nucleotides and Their Analysis by Capillary Electrophoresis

Contributors: Thomas M. Haas, Danye Qiu, Markus Häner, Larissa Angebauer, Alexander Ripp, Jyoti Singh, Hans-Georg Koch, Claudia Jessen-Trefzer, Henning J. Jessen
Publication Date: 2020-6-5

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Chemical Communications

Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

Contributors: Thomas M. Haas, Paul Ebensperger, Verena B. Eisenbeis, Christoph Nopper, Tobias Dürr, Nikolaus Jork, Nicole Steck, Claudia Jessen-Trefzer, Henning J. Jessen
Publication Date: 2019

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Cell Chemical Biology

Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol

Contributors: Miaomiao Li, Christoph Müller, Klemens Fröhlich, Oliver Gorka, Lin Zhang, Olaf Groß, Oliver Schilling, Oliver Einsle, Claudia Jessen-Trefzer
Publication Date: 2019-6

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ACS Central Science

Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria

Contributors: Amit K. Dutta, Eira Choudhary, Xuan Wang, Monika Záhorszka, Martin Forbak, Philipp Lohner, Henning J. Jessen, Nisheeth Agarwal, Jana Korduláková, Claudia Jessen-Trefzer
Publication Date: 2019-3

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ChemBioChem

New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant

Contributors: Songya Zhang, Jing Zhu, David L. Zechel, Claudia Jessen-Trefzer, Richard T. Eastman, Thomas Paululat, Andreas Bechthold
Publication Date: 2017

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Frontiers in Microbiology

Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains – An Unusual Secondary Metabolite with Various Properties

Contributors: Anja Greule, Marija Marolt, Denise Deubel, Iris Peintner, Songya Zhang, Claudia Jessen-Trefzer, Christian De Ford, Sabrina Burschel, Shu-Ming Li, Thorsten Friedrich, Irmgard Merfort, Steffen Lüdeke, Philippe Bisel, Michael Müller, Thomas Paululat, Andreas Bechthold
Publication Date: 2017-2

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Chemistry - A European Journal

A Modular Synthesis of Modified Phosphoanhydrides

Contributors: Alexandre Hofer, Gregor S. Cremosnik, André C. Müller, Roberto Giambruno, Claudia Trefzer, Giulio Superti-Furga, Keiryn L. Bennett, Henning J. Jessen
Publication Date: 2015-6-1

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European Journal of Immunology

The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response

Contributors: Barbara Herdy, Thomas Karonitsch, Gregory I. Vladimer, Chris S.H. Tan, Alexey Stukalov, Claudia Trefzer, Johannes W. Bigenzahn, Tamara Theil, Johannes Holinka, Hans P. Kiener, Jacques Colinge, Keiryn L Bennett, Giulio Superti-Furga
Publication Date: 2015-3

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Molecular Systems Biology

Targeting a cell state common to triple‐negative breast cancers

Contributors: Markus K Muellner, Barbara Mair, Yasir Ibrahim, Claudia Kerzendorfer, Hannelore Lechtermann, Claudia Trefzer, Freya Klepsch, André C Müller, Ernestine Leitner, Sabine Macho‐Maschler, Giulio Superti‐Furga, Keiryn L Bennett, José Baselga, Uwe Rix, Stefan Kubicek, Jacques Colinge, Violeta Serra, Sebastian MB Nijman
Publication Date: 2015-2

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Oncogene

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

Contributors: M P Licciardello, M K Müllner, G Dürnberger, C Kerzendorfer, B Boidol, C Trefzer, S Sdelci, T Berg, T Penz, M Schuster, C Bock, R Kralovics, G Superti-Furga, J Colinge, S M Nijman, S Kubicek
Publication Date: 2014-9

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Nature Chemical Biology

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Contributors: Georg E Winter, Branka Radic, Cristina Mayor-Ruiz, Vincent A Blomen, Claudia Trefzer, Richard K Kandasamy, Kilian V M Huber, Manuela Gridling, Doris Chen, Thorsten Klampfl, Robert Kralovics, Stefan Kubicek, Oscar Fernandez-Capetillo, Thijn R Brummelkamp, Giulio Superti-Furga
Publication Date: 2014-7

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Proceedings of the National Academy of Sciences

Correction for Wang et al., Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Contributors
Publication Date: 2013-9-9

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Proceedings of the National Academy of Sciences

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Contributors: F. Wang, D. Sambandan, R. Halder, J. Wang, S. M. Batt, B. Weinrick, I. Ahmad, P. Yang, Y. Zhang, J. Kim, M. Hassani, S. Huszar, C. Trefzer, Z. Ma, T. Kaneko, K. E. Mdluli, S. Franzblau, A. K. Chatterjee, K. Johnsson, K. Mikusova, G. S. Besra, K. Futterer, S. H. Robbins, S. W. Barnes, J. R. Walker, W. R. Jacobs, P. G. Schultz
Publication Date: 2013-6

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Journal of the American Chemical Society

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

Contributors: Claudia Trefzer, Henrieta Škovierová, Silvia Buroni, Adela Bobovská, Simone Nenci, Elisabetta Molteni, Florence Pojer, Maria R. Pasca, Vadim Makarov, Stewart T. Cole, Giovanna Riccardi, Katarína Mikušová, Kai Johnsson
Publication Date: 2011

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Journal of the American Chemical Society

Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis

Contributors: Claudia Trefzer, Monica Rengifo-Gonzalez, Marlon J. Hinner, Patricia Schneider, Vadim Makarov, Stewart T. Cole, Kai Johnsson
Publication Date: 2010-10-6

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Publications

Journal Articles

A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor

Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells

Deep Proteomic Investigation of Metabolic Adaptation in Mycobacteria under Different Growth Conditions

Increasing the Selectivity of Light‐Active Antimicrobial Agents – Or How To Get a Photosensitizer to the Desired Target

A Dual‐Metal‐Catalyzed Sequential Cascade Reaction in an Engineered Protein Cage**

Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis

Chemical biology in drug discovery

Inside a Shell – Organometallic Catalysis Inside Encapsulin Nanoreactors

Pyridinium Modified Anthracenes and Their Endoperoxides Provide a Tunable Scaffold with Activity against Gram-Positive and Gram-Negative Bacteria

Understanding the mechanism of action of pyrrolo[3,2-b]quinoxaline-derivatives as kinase inhibitors

The Two-Component Locus MSMEG_0244/0246 Together With MSMEG_0243 Affects Biofilm Assembly in M. smegmatis Correlating With Changes in Phosphatidylinositol Mannosides Acylation

Four Phosphates at One Blow: Access to Pentaphosphorylated Magic Spot Nucleotides and Their Analysis by Capillary Electrophoresis

Magic spot nucleotides: tunable target-specific chemoenzymatic synthesis

Detection and Characterization of a Mycobacterial L-Arabinofuranose ABC Transporter Identified with a Rapid Lipoproteomics Protocol

Trehalose Conjugation Enhances Toxicity of Photosensitizers against Mycobacteria

New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant

Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains – An Unusual Secondary Metabolite with Various Properties

A Modular Synthesis of Modified Phosphoanhydrides

The RNA-binding protein HuR/ELAVL1 regulates IFN-β mRNA abundance and the type I IFN response

Targeting a cell state common to triple‐negative breast cancers

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Correction for Wang et al., Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-β-d-ribofuranose 2′-Oxidase DprE1

Benzothiazinones: Prodrugs That Covalently Modify the Decaprenylphosphoryl-β-d-ribose 2′-epimerase DprE1 ofMycobacterium tuberculosis

Other Articles

Crystal structure of MSMEG_1712 from Mycobacterium smegmatis

Crystal structure of MSMEG_1712 from Mycobacterium smegmatis in complex with Beta-D-Galactofuranose

Crystal structure of MSMEG_1712 from Mycobacterium smegmatis in complex with alpha-L-arabinofuranose

Crystal structure of MSMEG_1712 from Mycobacterium smegmatis in complex with Beta-D-Fucofuranose